Preprints – Seyfried Lab

Preprint: Cerebrospinal fluid proteomics for predictive assessment of Alzheimer’s Disease risk

Saima Rathore, Eirc B Dammer, Ananth Shantaraman, Fang Wu, Duc M Duong, Edward J Fox, Erik C.B Johnson, James J Lah, Nicholas T Seyfried, Allan I Levey. Cerebrospinal fluid proteomics for predictive assessment of Alzheimer’s Disease risk. medRxiv 2025.10.24.25337921; doi:https://doi.org/10.1101/2025.10.24.25337921

Preprint: Non-linear associations of amyloid-β with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults.

Junjie Wu, Benjamin B Risk, Taylor A James, Nicholas Seyfried, David W Loring, Felicia C Goldstein, Allan I Levey, James J Lah, Deqiang Qiu. Non-linear associations of amyloid-β with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults. https://doi.org/10.48550/arXiv.2510.12751

Preprint: Multi-scale integration of human brain vasculature and CSF proteomes reveals biomarkers of cerebral amyloid angiopathy linked to Alzheimer’s disease risk

Aleksandra M Wojtas, Saima Rathore, Eric B Dammer, Lei Yu, Fatemeh Seifar, Joshna Gadhavi, Fang Wu, Anantharaman Shantaraman, Duc M Duong, Yue Liu, Adam N Trautwig, Edward J Fox, Kaylor M Kelly, Marla Gearing, Srikant Rangaraju, Sharham Oveisgharan, Gareth R Howell, Julie A Schneider, Edward B Lee, Vilas Menon, David A Bennett, James J Lah, […]

Preprint: Brain wide engraftment of human monocytes induces neurodegeneration and cognitive dysfunction.

Mathew Blurton-Jones, Hayk Davtyan, Jean Paul Chadarevian, Anita Lakatos, Sherry Lin, Jonathan Hasselmann, Jasmine Nguyen, Duc Duong, Joia Capocchi, Alina Lahian, Kimiya Mansour, Ghazaleh Eskandari-Sedighi, Christina Tu, Sepideh Kiani Shabestari, Fang Wu, Anantharaman Shantaraman, Michael Mgerian, Tau Lim, Alan Mai, Lauren Le, Ani Agababian, Elizabeth Head, Sandeep Robert Datta, Nicholas Seyfried. Brain wide engraftment of […]

Preprint: Multiplex Proteomics of Lewy Body Dementia Reveals Cerebrospinal Fluid Biomarkers of Disease Pathology and Progression

Higginbotham L, Shantaraman A, Guo Q, Fox EJ, Bagchi P, Wu F, Lah JJ, Levey AI, Seyfried NT. Multiplex Proteomics of Lewy Body Dementia Reveals Cerebrospinal Fluid Biomarkers of Disease Pathology and Progression. bioRxiv [Preprint]. 2025 Jun 13:2025.06.10.658994. doi: 10.1101/2025.06.10.658994. PMID: 40661363; PMCID: PMC12259125.

Preprint: Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling

Christina C. Ramelow, Eric B. Dammer, Hailian Xiao, Lihong Cheng, Prateek Kumar, Claudia Espinosa-Garcia, Maureen M. Sampson, Ruth S. Nelson, Sneha Malepati, Dilpreet Kour, Rashmi Kumari, Qi Guo, Pritha Bagchi, Duc M. Duong, Nicholas T. Seyfried, Steven A. Sloan, Srikant Rangaraju. Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling. bioRxiv 2025.01.29.635500; doi: https://doi.org/10.1101/2025.01.29.635500

Preprint: Identification of novel Kv1. 3 channel-interacting proteins using proximity labelling in T-cells.

Kour, D., Bowen, C.A., Srivastava, U., Nguyen, H.M., Kumari, R., Kumar, P., Brandelli, A.D., Bitarafan, S., Tobin, B.R., Wood, L.B. and Seyfried, N., 2025. Identification of novel Kv1. 3 channel-interacting proteins using proximity labelling in T-cells. bioRxiv, pp.2025-01. doi: https://doi.org/10.1101/2025.01.16.633279

Preprint: Autophagy-lysosomal dysfunction, intraneuronal amyloidosis, and selective neuron death yield senile plaques in preclinical late-onset Alzheimer’s Disease

Ralph Nixon, Ju-Hyun Lee, Philip Stavrides, Nicholas Seyfried et al. Autophagy-lysosomal dysfunction, intraneuronal amyloidosis, and selective neuron death yield senile plaques in preclinical late-onset Alzheimer’s Disease, 05 November 2024, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-5306901/v1]

Preprint: The YTHDF Proteins Shape the Brain Gene Signatures of Alzheimer’s Disease

Tasaki S, Avey DR, Kearns NA, Iatrou A, Yu C, De Tissera S, Vyas H, Xu J, Flood DJ, Rothamel K, Wingo AP, Wingo TS, Seyfried NT, De Jager PL, Yeo G, Gaiteri C, Bennett DA, Wang Y. The YTHDF Proteins Shape the Brain Gene Signatures of Alzheimer’s Disease. bioRxiv [Preprint]. 2024 Oct 23:2024.10.23.619425. doi: […]

Preprint: Systematic proteomics in Autosomal dominant Alzheimer’s disease reveals decades-early changes of CSF proteins in neuronal death, and immune pathways.

Yuanyuan Shen, Muhammad Ali, Menghan Liu, Jigyasha Timsina, Ciyang Wang, Anh Do, Daniel Western, Priyanka Gorijala, John Budde, Haiyan Liu, Brian Gordon, Nelly Joseph-Mathurin, Richard J Perrin, Eric McDade, John C Morris, Jorge J Llibre-Guerra, Randall J Bateman, Dario Maschi, Tony Wyss-Coray, Pau Pastor, Alan E Renton, Ezequiel I Surace, Erik CB Johnson, Ignacio Alvarez, […]