Preprints

Convergent effects of neurodevelopmental disorder-associated variants at mitochondria.

Maxine I. Robinette, Jada B. Gundy, Xinyan Leng, Duc Duong, Ananth Shantaraman, Liang Shi, Elizabeth A. Candelario, Anson Sing, Shubhangi Vibhor Garg, Weibo Niu, Nicholas T. Seyfried, Steven A. Sloan, Zhexing Wen, Joseph F. Cubells, Erica Duncan, Jennifer G. Mulle, Victor Faundez, Gary J. Bassell, Ryan H. Purcell. Convergent effects of neurodevelopmental disorder-associated variants at mitochondria. bioRxiv 2026.02.26.708316; doi: https://www.biorxiv.org/content/10.64898/2026.02.26.708316v1

Balanced deep learning on multi-omics networks identifies molecular subgroups of pathological brain aging.

Yacoub Abelard Njipouombe Nsangou, Maria A. Ulmer, Nicholas T. Seyfried, Jürgen Dönitz, Alzheimer’s Disease Metabolomics Consortium, The AMP-AD Consortium, Rima Kaddurah-Daouk, Gabi Kastenmüller, Matthias Arnold. Balanced deep learning on multi-omics networks identifies molecular subgroups of pathological brain aging. medRxiv 2026.02.18.26346567; doi: https://www.medrxiv.org/content/10.64898/2026.02.18.26346567v1

Preprint: Non-linear associations of amyloid-β with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults.

Junjie Wu, Benjamin B Risk, Taylor A James, Nicholas Seyfried, David W Loring, Felicia C Goldstein, Allan I Levey, James J Lah, Deqiang Qiu. Non-linear associations of amyloid-β with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults.  https://doi.org/10.48550/arXiv.2510.12751

Preprint: Multi-scale integration of human brain vasculature and CSF proteomes reveals biomarkers of cerebral amyloid angiopathy linked to Alzheimer’s disease risk

Aleksandra M Wojtas, Saima Rathore, Eric B Dammer, Lei Yu, Fatemeh Seifar, Joshna Gadhavi, Fang Wu, Anantharaman Shantaraman, Duc M Duong, Yue Liu, Adam N Trautwig, Edward J Fox, Kaylor M Kelly, Marla Gearing, Srikant Rangaraju, Sharham Oveisgharan, Gareth R Howell, Julie A Schneider, Edward B Lee, Vilas Menon, David A Bennett, James J Lah, […]

Preprint: Brain wide engraftment of human monocytes induces neurodegeneration and cognitive dysfunction.

Mathew Blurton-Jones, Hayk Davtyan, Jean Paul Chadarevian, Anita Lakatos, Sherry Lin, Jonathan Hasselmann, Jasmine Nguyen, Duc Duong, Joia Capocchi, Alina Lahian, Kimiya Mansour, Ghazaleh Eskandari-Sedighi, Christina Tu, Sepideh Kiani Shabestari, Fang Wu, Anantharaman Shantaraman, Michael Mgerian, Tau Lim, Alan Mai, Lauren Le, Ani Agababian, Elizabeth Head, Sandeep Robert Datta, Nicholas Seyfried. Brain wide engraftment of […]

Preprint: Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling

Christina C. Ramelow, Eric B. Dammer, Hailian Xiao, Lihong Cheng, Prateek Kumar, Claudia Espinosa-Garcia, Maureen M. Sampson, Ruth S. Nelson, Sneha Malepati, Dilpreet Kour, Rashmi Kumari, Qi Guo, Pritha Bagchi, Duc M. Duong, Nicholas T. Seyfried, Steven A. Sloan, Srikant Rangaraju. Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling. bioRxiv 2025.01.29.635500; doi: https://doi.org/10.1101/2025.01.29.635500

Preprint: Autophagy-lysosomal dysfunction, intraneuronal amyloidosis, and selective neuron death yield senile plaques in preclinical late-onset Alzheimer’s Disease

Ralph Nixon, Ju-Hyun Lee, Philip Stavrides, Nicholas Seyfried et al. Autophagy-lysosomal dysfunction, intraneuronal amyloidosis, and selective neuron death yield senile plaques in preclinical late-onset Alzheimer’s Disease, 05 November 2024, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-5306901/v1]