Preprints – Seyfried Lab

Autophagy-lysosomal dysfunction, intraneuronal amyloidosis, and selective neuron death yield senile plaques in preclinical late-onset Alzheimer’s Disease

Ralph Nixon, Ju-Hyun Lee, Philip Stavrides, Nicholas Seyfried et al. Autophagy-lysosomal dysfunction, intraneuronal amyloidosis, and selective neuron death yield senile plaques in preclinical late-onset Alzheimer’s Disease, 05 November 2024, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-5306901/v1]

Preprint: Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer’s Disease and Older Controls in Multi-Ethnic Populations.

Joseph S. Reddy, Laura Heath, Abby Vander Linden, Mariet Allen, Katia de Paiva Lopes, Fatemeh Seifar, Erming Wang, Yiyi Ma, William L. Poehlman, Zachary S. Quicksall, Alexi Runnels, Yanling Wang, Duc M. Duong, Luming Yin, Kaiming Xu, Erica S. Modeste, Anantharaman Shantaraman, Eric B. Dammer, Lingyan Ping, Stephanie R. Oatman, Jo Scanlan, Charlotte Ho, Minerva […]

Preprint: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

Rowan Saloner, Adam Staffaroni, Eric Dammer, Nicholas Seyfried et al. Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration, 28 March 2024, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-4103685/v1]

Preprint: Network Analysis of the Cerebrospinal Fluid Proteome Reveals Shared and Unique Differences Between Sporadic and Familial Forms of Amyotrophic Lateral Sclerosis

Adam N. Trautwig, Edward J. Fox, Eric B. Dammer, Anantharaman Shantaraman, Lingyan Ping, Duc M. Duong, Allan I. Levey, James J. Lah, Christina N. Fournier, Zachary T. McEachin, Jonathan D. Glass, Nicholas T. Seyfried. Network Analysis of the Cerebrospinal Fluid Proteome Reveals Shared and Unique Differences Between Sporadic and Familial Forms of Amyotrophic Lateral Sclerosis. doi: https://doi.org/10.1101/2024.02.29.582840

Preprint: Integrative brain omics approach reveals key role for sn-1 lysophosphatidylethanolamine in Alzheimer’s dementia.

Ortlund E, Chen C-Y, Maner-Smith K, Khadka M, Ahn J, Gulbin X, Ivanova A, Dammer E, Seyfried N, Bennett D. Integrative brain omics approach reveals key role for sn-1 lysophosphatidylethanolamine in Alzheimer’s dementia. PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-3973736/v1]

Preprint: An interim exploratory biomarker analysis of a Phase 2 clinical trial to assess the impact of CT1812 in Alzheimer’s disease.

Lizama B, North H, Pandey K, Williams C, Duong D, Cho E, Caro VD, Ping L, Blennow K, Zetterberg H, Lah J, Levey A, Grundman M, Caggiano A, Seyfried N, Hamby M. An interim exploratory biomarker analysis of a Phase 2 clinical trial to assess the impact of CT1812 in Alzheimer’s disease. bioRxiv. 2024:2024.02.16.578765. doi: […]

Preprint: Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer’s Disease

Anantharaman Shantaraman, Eric B. Dammer, Obiadada Ugochukwu, Duc M. Duong, Luming Yin, E. Kathleen Carter, Marla Gearing, Alice Chen-Plotkin, Edward B. Lee, John Q. Trojanowski, David A. Bennett, James J. Lah, Allan I. Levey, Nicholas T. Seyfried, Lenora Higginbotham. Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer’s Disease. https://doi.org/10.1101/2024.01.23.576728

Preprint: Systematic proteomics in Autosomal dominant Alzheimer’s disease reveals decades-early changes of CSF proteins in neuronal death, and immune pathways.

Yuanyuan Shen, Muhammad Ali, Menghan Liu, Jigyasha Timsina, Ciyang Wang, Anh Do, Daniel Western, Priyanka Gorijala, John Budde, Haiyan Liu, Brian Gordon, Nelly Joseph-Mathurin, Richard J Perrin, Eric McDade, John C Morris, Jorge J Llibre-Guerra, Randall J Bateman, Dario Maschi, Tony Wyss-Coray, Pau Pastor, Alan E Renton, Ezequiel I Surace, Erik CB Johnson, Ignacio Alvarez, […]

Preprint: Proteomic Changes in the Human Cerebrovasculature in Alzheimer’s Disease and Related Tauopathies Linked to Peripheral Biomarkers in Plasma and Cerebrospinal Fluid

Aleksandra M. Wojtas, Eric B. Dammer, Qi Guo, Lingyan Ping, Ananth Shantaraman, Duc M. Duong, Luming Yin, Edward J. Fox, Fatemeh Seifar, Edward B. Lee, Erik C.B. Johnson, James J. Lah, Allan I. Levey, Yona Levites, Srikant Rangaraju, Todd E. Golde, Nicholas T. Seyfried. Proteomic Changes in the Human Cerebrovasculature in Alzheimer’s Disease and Related […]

Preprint: Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer’s Disease.

Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M, Gadhavi J, Lolo K, Trejo-Lopez J, Phillips JL, Iturbe A, Erqiuzi A, Moore BD, Ryu D, Natu A, Dillon KD, Torrellas J, Moran C, Ladd TB, Afroz KF, Islam T, Jagirdar J, Funk CC, Robinson M, Borchelt DR, Ertekin-Taner N, Kelly JW, Heppner […]