Trautwig AN, Fox EJ, Dammer EB, Shantaraman A, Ping L, Duong DM, Watson CM, Wu F, Asress S, Guo Q, Levey AI, Lah JJ, Verde F, Doretti A, Ratti A, Ticozzi N, Ly CV, Miller TM, Garret MA, Berry JD, Thomas EV, Fournier CN, McEachin ZT, Seyfried NT, Glass JD. Network analysis of the cerebrospinal […]
Mei Z, Liu J, Bennett DA, Seyfried N, Wingo AP, Wingo TS. Unraveling sex differences in Alzheimer’s disease and related endophenotypes with brain proteomes. Alzheimers Dement. 2025 May;21(5):e70206. doi: 10.1002/alz.70206. PMID: 40346727; PMCID: PMC12064417.
Lish AM, Grogan EFL, Benoit CR, Pearse RV 2nd, Heuer SE, Luquez T, Orme GA, Galle PC, Milinkeviciute G, Green KN, Alexander KD, Fancher SB, Stern AM, Fujita M, Bennett DA, Seyfried NT, De Jager PL, Menon V, Young-Pearse TL. CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density. Neuron. 2025 […]
Tandon R, Zhao L, Watson CM, Sarkar N, Elmor M, Heilman C, Sanders K, Hales CM, Yang H, Loring DW, Goldstein FC, Hanfelt JJ, Duong DM, Johnson ECB, Wingo AP, Wingo TS, Roberts BR, Seyfried NT, Levey AI, Lah JJ, Mitchell CS, Initiative AsDN. Stratifying risk of Alzheimer’s disease in healthy middle-aged individuals with machine […]
Zhao J, Gu T, Gao C, Miao G, Palma-Gudiel H, Yu L, Yang J, Wang Y, Li Y, Lim J, Li R, Yao B, Wu H, Schneider JA, Seyfried N, Grodstein F, De Jager PL, Jin P, Bennett DA. Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer’s disease neuropathology. Nat Commun. 2025 Mar 22;16(1):2842. doi: 10.1038/s41467-025-58159-w. […]
Moore J, Wu T, Dhindsa J, El Fadel O, Le A, Perez A, Amoh B, Tarkunde A, Zhu KF, Avalos M, Dammer EB, Duong DM, Seyfried NT, Shulman JM, Al-Ramahi I, Botas J. Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson’s disease. NPJ Parkinsons Dis. 2025 Mar 11;11(1):46. doi: 10.1038/s41531-025-00899-z. […]
Hajós M, Pandey K, Singer AC, Duong D, Bitarafan S, Shpokayte M, Malchano Z, Kern R, Lah JJ, Levey AI, Seyfried NT. CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment. Alzheimers Dement (N Y). 2025 Feb 11;11(1):e70051. doi: 10.1002/trc2.70051. PMID: 39935616; PMCID: PMC11812123.
Thomas EV, Han C, Kim WJ, Asress S, Li Y, Taylor JA, Gearing M, Fournier CN, McEachin ZT, Seyfried NT, Glass JD. ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression. Ann Clin Transl Neurol. 2025 Feb 6. doi: 10.1002/acn3.70001. PMID: 39913612.
Huhe H, Shapley SM, Duong DM, Wu F, Ha SK, Choi SH, Kofler J, Mou Y, Guimaraes TR, Thathiah A, Watson CM, Schaeffer LKH, Carter GW, Seyfried NT, Silva AC, Sukoff Rizzo SJ. Marmosets as model systems for the study of Alzheimer’s disease and related dementias: Substantiation of physiological tau 3R and 4R isoform expression […]