2025

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures.

Alexandra M. Lish, Nancy Ashour, Richard V. Pearse, Paige C. Galle, Gwendolyn A. Orme, Sarah E. Heuer, Courtney R. Benoit, Kellianne D. Alexander, Elyssa F.L. Grogan, Gizem Terzioglu, Allegra Scarpa, Andrew M. Stern, Nicholas Seyfried, Vilas Menon, Tracy L. Young-Pearse. Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human […]

Identification of cerebrospinal fluid pharmacodynamic biomarkers and molecular correlates of brain activity in a Phase 2 clinical trial of the Alzheimer’s disease drug candidate CT1812.

Di Caro V, Cho E, North HA, Caldwell J, Pandey K, Duong D, Grundman M, de Haan W, Vijverberg EG, Teunissen CE, Caggiano AO, Seyfried NT, Hamby ME. Identification of cerebrospinal fluid pharmacodynamic biomarkers and molecular correlates of brain activity in a Phase 2 clinical trial of the Alzheimer’s disease drug candidate CT1812. Alzheimers Dement […]