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Proteins in cerebrospinal fluid can provide an early indication about the likelihood of future Alzheimer’s-related cognitive decline, according to recently published research findings out of Emory University in Atlanta. Individuals who know they have elevated levels of these proteins could pursue “diet or lifestyle interventions,” although the research team still does not know whether the […]

A team led by researchers at Emory University has identified a panel of cerebrospinal fluid proteins linked to Alzheimer’s disease. Detailed in a study published this month in Science Translational Medicine, the 48-protein panel could improve the performance of existing diagnostic markers for Alzheimer’s as well as help predict progression of the disease, said Nicholas Seyfried, professor of […]

Two teams of Emory researchers have discovered proteins in human cerebrospinal fluid that can serve as early indicators that the patient may develop Alzheimer’s disease in the future. Read more at https://news.emory.edu/stories/2023/09/hs_alzheimers_biomarkers_14_09_23/story.html

A panel of 48 CSF proteins—Aβ or tau not among them—distinguished people with Alzheimer’s from controls with 94 percent accuracy, according to a study published September 6 in Science Translational Medicine. Adding classic AD biomarkers to this curated panel bumped up accuracy even more. The work was led by Thomas Wingo, Nicholas Seyfried, and Allan […]

Grayson received his M.S. from Georgia Institute of Technology.  He helped develop a mechanical intervention for intracranial hemorrhage as a part of his M.S. program, and aided in research at Tech’s ARM Lab investigating cognitive burden from compliant device usage. He previously worked on research into electrical therapies for Parkinson’s Disease at both Mayo Clinic […]

Congratulation to Cheyenne Hurst and the rest of the team for your hard work preparing “Genetic background influences the 5XFAD Alzheimer’s disease mouse model brain proteome” for publication in Frontiers in Aging Neuroscience, section Alzheimer’s Disease and Related Dementias. Preprint available at https://news.emory.edu/stories/2023/09/hs_alzheimers_biomarkers_14_09_23/story.html

Congratulation to Lenora Higginbotham, Kathleen Carter, and the rest of the team on your hard work preparing “Unbiased Classification of the Elderly Human Brain Proteome Resolves Distinct Clinical and Pathophysiological Subtypes of Cognitive Impairment” for publication in Neurobiology of Disease. Preprint available at https://news.emory.edu/stories/2023/09/hs_alzheimers_biomarkers_14_09_23/story.html

Some of the proteins showed changes only in blood plasma but not in brain tissue, which suggests that “mechanisms below the neck could also play a role”, says neurologist Nicholas Seyfried. Full briefing: ““Dementia risk linked to blood-protein imbalance in middle age”