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Congratulations to graduate student Fatemeh Seifar on her first-author publication in Alzheimer’s & Dementia journal! This multi-institutional study delivers a comprehensive analysis of the proteomic landscape in Alzheimer’s disease (AD) across diverse racial groups, leveraging data from 1,105 brain tissues. The study reveals no significant racial differences in key AD proteins, including amyloid and tau, but identifies distinct variations in other protein groups associated with race and diagnosis.

Figure 1 from Large-scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14360

Congratulations, Sarah Shapley on her first author manuscript published this month! In collaboration with Dr. Stacey Rizzo’s team at the University of Pittsburgh, we investigated the presence of tau in marmoset brains to establish the foundational translatability of this animal model to human disease. Tau was not only present in adult marmoset brains, but also found to be at a ~40%:60% ratio of 3R:4R.

Figure 2 image from Marmosets as model systems for the study of Alzheimer's disease

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14366

Congratulations to Fatemeh Seifar for winning the AAIC conference fellowship to present her research!

Fatemeh presenting her work at AAIC.

Fatemeh Seifar, MD, graduate student in neuroscience, presented her PhD work on Proteomic Analysis of Alzheimer’s Disease Brains Across Diverse Racial Groups at The Alzheimer’s Association International Conference (AAIC) in Philadelphia. She was awarded the conference fellowship from Alzheimer’s Association to attend this conference.